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Great points, and thanks for reading and commenting! Yes, L-methionine is the natural stereoisomer. And yes, good point that homocysteine, downstream of L-methionine in the transsulfuration pathway, is deleterious. Here are 2 reviews on the health effects of methionine: https://pubmed.ncbi.nlm.nih.gov/31515518/ (subscription required) and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508608/ -- but you are right that as Paracelsus said, the dose makes the poison, in that too much or too little is harmful.

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Brent R. Stockwell, Ph.D.
Brent R. Stockwell, Ph.D.

Written by Brent R. Stockwell, Ph.D.

Chair and Professor of Biological Sciences at Columbia University. Top Medium writer in Science, Creativity, Health, and Ideas

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